RESEARCH
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PHOTOCATALYSIS
Our lab focuses on advancing organic synthesis through photoredox and asymmetric catalysis. By harnessing visible light, we drive reactions that form complex, chiral molecules with high precision. This innovative approach enables the efficient construction of enantiopure compounds, which are crucial in pharmaceuticals and materials science. Our research aims to develop sustainable methodologies that streamline the synthesis of these vital compounds.
EDA CHEMISTRY
Our lab advances organic synthesis through electron donor–acceptor (EDA) complexes, which form between electron-rich donors and electron-deficient acceptors. These complexes enable reactions under mild conditions without the need for external catalysts, offering a more sustainable alternative to traditional photoredox catalysis. This approach facilitates efficient and selective transformations, expanding the toolkit for constructing complex molecules essential in pharmaceuticals and materials science.
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PEPTIDE CATALYSIS
Peptide catalysis harnesses the modular and tunable properties of synthetic peptides to drive asymmetric transformations with exceptional selectivity. This biomimetic approach enables access to novel multifunctional substrate activation modes, overcoming challenges of conventional catalysis. Significant challenges include achieving precise structural control and expanding substrate scope. Our lab innovates by designing conformationally dynamic peptides and exploring new catalytic frameworks to address these limitations, paving the way for sustainable and versatile synthetic methodologies.
Protein Bioconjugation
Our lab specializes in protein bioconjugation, focusing on the chemoselective labeling and profiling of amino acids. This technique enables precise modification of proteins, facilitating the study of their functions and interactions. Innovatively, we employ bioorthogonal reactions, such as strain-promoted alkyne–azide cycloaddition, to achieve selective labeling under physiological conditions. Challenges include achieving site-specificity and maintaining protein integrity. We address these by developing novel reagents and optimizing reaction conditions to enhance selectivity and preserve protein function.
